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One possible explanation for this finding is that limited Grx activity is needed to maintain the correct balance between Mia40 and the GSH pool, and that Grx2 – speculatively by catalyzing GSH-dependent disulfide bond isomerization or reduction of disulfides – provides a kinetic barrier that prevents GSH-mediated reduction of Mia40 substrates (Fig

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Steroids, on the other hand, are lipid-based compounds derived from cholesterol